Dealings in Securities by Directors Cilo Cybin Holdings Limited Incorporated in the Republic of South Africa (Registration number 2022/320351/06) Share code: CCC ISIN: ZAE000310397 ("Cilo Cybin" or "the Company") DEALINGS IN SECURITIES BY DIRECTORS In compliance with paragraphs 3.63 – 3.74 (both inclusive) of the Listings Requirements of the JSE Limited, the following information is disclosed: Name of director: Ms Jessica Moodley-Theron Company: Cilo Cybin Class of securities: Cilo Cybin ordinary shares Nature of transaction: Purchase of shares on market Extent of director's interest: Direct beneficial Clearance to deal obtained: Yes Date of transaction: 27 March 2025 Number of securities: 1 050 Price of the security: R4.02 Total value: R4 221.00 Date of transaction: 28 March 2025 Number of securities: 1 100 Price of the security: R4.02 Total value: R4 422.00 Name of director: Mr Gabriel Christiaan Theron Company: Cilo Cybin Class of securities: Cilo Cybin ordinary shares Nature of transaction: Purchase of shares on market Extent of director's interest: Direct beneficial Clearance to deal obtained: Yes Date of transaction: 28 March 2025 Number of securities: 2 000 Price of the security: R4.02 Total value R8 040.00 Johannesburg 28 March 2025 Designated Advisor Merchantec Capital Date: 28-03-2025 05:05:00 Produced by the JSE SENS Department. The SENS service is an information dissemination service administered by the JSE Limited ('JSE'). The JSE does not, whether expressly, tacitly or implicitly, represent, warrant or in any way guarantee the truth, accuracy or completeness of the information published on SENS. The JSE, their officers, employees and agents accept no liability for (or in respect of) any direct, indirect, incidental or consequential loss or damage of any kind or nature, howsoever arising, from the use of SENS or the use of, or reliance on, information disseminated through SENS.